Dr. Costanzi's research interests mainly revolve around the application of computational techniques to the study of drug targets and the identification of molecules that modulate their activity. The main focus of the research activities is on the study of G protein-coupled receptors (GPCRs), the single family of drug targets most exploited by currently marketed medicines. Importantly, Dr. Costanzi’s research significantly contributed to defining and expanding the scope of applicability of computational modeling to the study of GPCRs and the discovery of their modulators. Dr. Costanzi’s interests also include the integration of computational and experimental research, through collaborations with experimental chemists and biologists.
For a list of Dr. Costanzi's publications, see Google Scholar
Dr. Costanzi received a BS/MS degree (laurea) in Chemistry, with a Biochemistry Curriculum, from the University of Camerino in 1997, and a Ph.D. degree in Medicinal Chemistry from the same University in 2000. In 1999 he spent 6 months in the Bioorganic and Biological Chemistry Laboratory of the University of Hull (UK). After his Ph.D. degree, Dr. Costanzi completed his studies with four years of postdoctoral experience conducted at the University of Camerino and at the National Institutes of Health (NIH). Subsequently, prior to moving to American University, Dr. Costanzi was employed as a staff scientist at the National Institute of Diabetes and Digestive and Kidney Diseases of the NIH, were he headed a research group focused on the rational discovery of pharmacologically active molecules.